Thumbnail Image
Dr 

Osunsanmi, Foluso Oluwagbemiga

Faculty: Faculty of Science, Agriculture and Engineering
Department: Agriculture
Research Interest(s): Clinical biochemistry, Bio-informatics, Food biochemistry, Plants biochemistry, Medicinal chemistry, Ethno-pharmacology, Natural product synthetic chemistry, Functional food, Metabolic diseases, Nutritional biochemistry, Microbiology, Biotechnology, Proteomics.
Biography: Dr. Foluso O Osunsanmi is currently a Research Fellow at the Department of Biochemistry and Microbiology, University of Zululand, South Africa. He is a biochemist with twenty years’ work experiences both in academic and industrial sectors. He had supervised both undergraduate and postgraduate students. He also has notable numbers of publications in reputable journals and had presented both in local and international conferences. He regularly performs peer reviews for over twenty-two different reputable journals. He is an Academic Editor of many International journals. He is also member of South Africa Association Council for Natural Scientific Professions, South Africa Association of Clinical Biochemistry, South Africa Association of Botanist and National Association of Safety professional.
Views

34

Downloads

0

Your Rating
N/A
Avg. Rating
0/5
( 0 Reviews )
Rating Breakup
1
0
2
0
3
0
4
0
5
0

Rating this item

FacebookXWhatsAppLinkedIn

More Detail

20191
End date: 2019 × Start date: 2019 ×
Reset filters

Search Results

Now showing 1 - 1 of 1
  • Thumbnail Image
    PublicationJournal Article
    FacebookXWhatsAppLinkedIn
    Protein isolate from Parkia biglobosa seeds improves dyslipidaemia and cardiac oxidative stress in streptozotocin-induced diabetic rats
    2019
     | MDPI
    Reports from previous studies now provide evidence that dyslipidaemia and oxidative stress play crucial roles in the pathogenesis and progression of diabetes and its related complications. This research is aimed to investigate the potential effects of protein isolate from Parkia biglobosa seeds (PBPI) in streptozotocin (STZ)-induced diabetic rats by measuring blood glucose levels, changes in lipid metabolism and biomarkers of oxidative stress. Diabetic rats were treated orally with graded doses of PBPI, 200 mg/kg bw and 400 mg/kg bw, and 5 U/kg, intraperitoneal (i.p.) of insulin once daily for 28 days with the fasting blood glucose (FBG) monitored weekly. The effect of PBPI on the serum lipid profile was measured while the extent of lipid peroxidation (LPO), as well as antioxidant parameters (superoxide dismutase; SOD, catalase; CAT, glutathione-S-transferase; GST and total glutathione; total GSH), was determined in the cardiac homogenates of diabetic rats. At the tested doses, treatment with PBPI was significantly effective in lowering FBG, serum triglyceride, cholesterol, low-density lipoprotein cholesterol (LDL-c) and very low-density lipoprotein cholesterol (VLDL-c), while concurrently increasing high-density lipoprotein cholesterol (HDL-c). PBPI also significantly decreased the elevations witnessed in LPO levels and restored the biomarkers of oxidative stress in the cardiac homogenate of experimental rats. The results from this study demonstrate that PBPI could improve dyslipidaemia and cardiac oxidative stress in the experimental diabetic animal model possibly by reducing and effectively scavenging reactive oxygen species (ROS) production as well as by increasing antioxidant capacity in combating oxidative stress. Therefore, it can be concluded that PBPI could be explored in the development of a potent cardioprotective supplement or adjuvant therapy towards the management of diabetes and its related complications.
    • 1
    • 4
    • 0