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Prof 

Zharare, Godfrey Elijah

Faculty: Faculty of Science, Agriculture and Engineering
Department: Agriculture
ORCID: https://orcid.org/0000-0003-2341-4719
Research Interest(s): Extraction and Physiochemical properties of essential and Vegetable oils, Botany and genetics of oil-bearing plants, Cosmeceutical, pharmaceatical utilization od esseantial, and vegetable oils.
Active Research Project(s): Bio-refinery of Strychnos madagascariensis fruit (Ikwakwa). Validation of Ikwaflakes and Kwafee as nutraceutical foods for managing Hyperlipidaemia, Diabetes, and Hypertension. Optimization of Oil Extraction from Strychnos madagascariensis and Technology Transfer. Variation in morphology, Proximate components, and Genetic attributes of Strychic spinosa genotypes. Morphological variation, Genetics, Volatile oil yield in Laggera alata, and Laggera crispata species in Northern KwaZulu-Natal, South Africa.
Active Community Engagement: UNIZULU King Cetshwayo District Content Workshop for grade 10-12 economics educators (2021).
Biography: Prof G.E. Zharare is Professor under Agriculture Department in the Faculty of Science, Agriculture and Engineering at the University of Zululand. He is Plant Scientist with specialization in Agronomy and plant physiology. Prof Zharare is an NRF C3 rated researcher who has published numerous peer-reviewed articles. He has supervised many postgraduate students to completion in plant sciences. He also acts as a reviewer for a number of international journals on plant sciences.
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20221
Subject: Acetylcholinesterase ×
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    PublicationJournal Article
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    Effects of methanolic crude extracts Inula glomerata and Salacia kraussii on erectile dysfunction
    2022
     | Bioline Internationa...
    Inula glomerata Oliv. & Hiern and Salacia kraussii (Harv.) Harv are medicinal plants used by traditional healers in remote areas of Mbazwana, Northern KwaZulu-Natal, South Africa for ameliorating male sexual disorders including erectile dysfunction (ED), low sperm count and early ejaculation. The study aimed at determining the ameliorative effect of the methanolic crude extracts of Inula glomerata (I. glomerata) and Salacia kraussii (S. kraussii) on butanol-induced erectile dysfunction in Sprague Dawley rats. The crude extract was prepared by maceration using methanol. Animal study was conducted whereby thirty-five male Sprague Dawley rats were divided into seven experimental groups: normal group, n-but (10 mg/kg), n-but+ Ig (50 and 250 mg/kg), n-but+ Sk (50 and 250 mg/kg) and n-but+ Cialis (5mg/kg). The experiment lasted for 28 days, after which various biochemical assays (acetylcholinesterase, ACE, arginase, testosterone, and uric acid) was done. The cytotoxicity of the crude extracts was also determined. The results revealed that n-butanol induced erectile dysfunction in the rats by decreasing mounting frequency, testosterone and nitric oxide level and simultaneously elevated the activities of arginase and acetylcholinesterase. The plants however, inhibited arginase and acetylcholinesterase when compared to the untreated. Furthermore, the plants’ extracts were able to increase the level of testosterone and nitric oxide. It can be inferred that both plants could be promising natural therapy for erectile dysfunction. Nonetheless, the plants’ extracts are toxic hence should be taken with caution.
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