Syringic acid demonstrates an anti-inflammatory effect via modulation of the NF-κB-iNOS-COX-2 and JAK-STAT signaling pathways in methyl cellosolve-induced hepato-testicular inflammation in rats

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dc.contributor.authorOyinloye, Babatunji Emmanuel
dc.contributor.authorSomade, Oluwatobi
dc.contributor.authorAjiboye, Basiru Olaitan
dc.contributor.authorOsukoya, Olukemi Adetutu
dc.coverage.conferenceissn
dc.date.accessioned2026-05-11T13:17:27Z
dc.date.available2026-05-11T13:17:27Z
dc.date.issued2023
dc.departmentNameBiochemistry and Microbiology
dc.description.abstractSyringic acid (SACI) is an emerging nutraceutical and antioxidant used in modern Chinese medicine. It has potential neuroprotective, anti-hyperglycemic, and anti-angiogenic properties. Methyl cellosolve (MCEL) has been reported to induce tissue inflammation in the testis, kidney, liver, and lung. This study aimed to investigate the effect and probable mechanism of action of SACI on MCEL-induced hepatic and testicular inflammation in male rats. Compared to the control group, administration of MCEL to rats significantly increased the levels of IL-6, TNF-α, iNOS, COX-2, and NF-κB in the liver and testis. Additionally, the total mRNA expressions of JAK1 (in the liver only), STAT1, and SOCS1 were significantly increased in both the liver and testis, while testicular JAK1 total mRNA levels were significantly decreased. The expression of PIAS1 protein was significantly higher in the liver and testis. Treatments with SACI at 25 (except liver iNOS), 50, and 75 mg/kg significantly decreased the levels of IL-6, TNF-α, iNOS, COX-2, and NF-κB compared to the control group. Furthermore, the total mRNA expressions of JAK1 and SOCS1 in the liver were significantly reduced by all doses of SACI investigated, while the total mRNA levels of liver and testis STAT1 were significantly reduced by 25 and 50 mg/kg of SACI only. In the testis, the mRNA level of SOCS1 was significantly reduced by all doses of SACI compared to MCEL only. Additionally, SACI (at 75 mg/kg) significantly reduced PIAS1 protein expression in the liver, while in the testis, SACI at all investigated doses significantly reduced the expression of PIAS1. In conclusion, SACI demonstrated a hepatic and testicular anti-inflammatory effect by inhibiting the MCEL-induced activation of the NF-κB and JAK-STAT signaling pathways in rats.
dc.facultyFaculty of Science, Agriculture and Engineering
dc.identifier.citationSomade, O.T. et al. 2023. Syringic acid demonstrates an anti-inflammatory effect via modulation of the NF-κB-iNOS-COX-2 and JAK-STAT signaling pathways in methyl cellosolve-induced hepato-testicular inflammation in rats. Biochemistry and Biophysics Reports, 34, pp.1-12.
dc.identifier.issn2405-5808 (online)
dc.identifier.otherhttps://doi.org/10.1016/j.bbrep.2023.101484
dc.identifier.urihttp://hdl.handle.net/10530/59813
dc.inproceedingsissn
dc.issuenumber34
dc.keynoteissn
dc.language.isoEnglish
dc.pages1 - 12
dc.peerreviewedYes
dc.publisherElsevier
dc.subjectMethyl cellosolve
dc.subjectSyringic acid
dc.subjectNf-κb
dc.subjectCytokines
dc.subjectJanus kinase (JAK1)
dc.subjectSignal transducer and activator of transcription (STAT1)
dc.titleSyringic acid demonstrates an anti-inflammatory effect via modulation of the NF-κB-iNOS-COX-2 and JAK-STAT signaling pathways in methyl cellosolve-induced hepato-testicular inflammation in rats
dc.title.journalBiochemistry and Biophysics Reports
dc.typeJournal Article
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery7a853ed9-a20d-49e7-b740-c303f88993a2
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