Development of bacterial resistant acrylamide-polyvinylpyrrolidonemetal oxide hydrogel nanocomposites

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dc.contributor.authorRevaprasadu, Neerish
dc.contributor.authorOwonubi, Shesan John
dc.contributor.authorAgwuncha S.C.
dc.contributor.authorMalima, Nyemaga Masanje
dc.contributor.authorSadiku E.R.
dc.coverage.conferenceissn
dc.date.accessioned2025-11-23T11:48:19Z
dc.date.available2025-11-23T11:48:19Z
dc.date.issued2021
dc.departmentNameChemistry
dc.description.abstractFabrication of polymer-based nanocomposites for numerous biomedical applications represents a predominant form of therapeutics for combating microbial and bacterial infections. Herein, we firstly synthesized metal oxide nanoparticles (MONPs) by previously reported precipitation methods. Hydrogel nanocomposites were then prepared by free radical polymerization of a combination of the synthesized MONPs, polyvinylpyrrolidone (PVP) and acrylamide. The hydrogel nanocomposites were characterized by FTIR, XRD and investigated for potential antibacterial protection. FTIR spectra of the prepared hydrogel nanocomposites revealed significant characteristic peaks of the distinctive MONPs within the polymer matrix. XRD micrographs revealed slight shifting of peak positions in nanocomposites; the change in peak intensity, coupled with the observed slight shift in the diffraction peaks of both CuO and ZnO nanoparticles confirmed the successful incorporation of the MONPs into the polymer matrix. The presence of the MONPs, in combination with PVP, displayed a synergistic antibacterial activity, with increasing concentration of the MONPs. The treatment against S.pneumoniae, revealed a zone of inhibition phenomenon which showed zones of PVP-5 > PVP-8 > PVP-6 > PVP-9 > PVP-7. PVP-1, PVP-2, PVP-3, PVP-4 did not show any significant zone of inhibition on treatment due to the quantity of MONPs present. The findings show that the hydrogel nanocomposites are potential topical wound dressing materials for the management of bacterial infections.
dc.facultyFaculty of Science, Agriculture and Engineering
dc.format.preprintNo
dc.identifier.citationOwonubi, S.J., Agwuncha, S.C., Malima, N.M., Sadiku, E.R. and Revaprasadu, N., 2021. Development of bacterial resistant acrylamide-polyvinylpyrrolidone-metal oxide hydrogel nanocomposites. Materials Today: Proceedings, 38, pp.982-987.
dc.identifier.issn2214-7853
dc.identifier.otherhttps://doi.org/10.1016/j.matpr.2020.05.502
dc.identifier.urihttp://hdl.handle.net/10530/58351
dc.inproceedingsissn
dc.issuenumber38 / 2
dc.keynoteissn
dc.pages982 - 987
dc.peerreviewedYes
dc.publisherElsevier
dc.subjectMetal oxide
dc.subjectNanocomposite
dc.subjectHydrogels
dc.subjectAntibacterial
dc.subjectPolymer
dc.titleDevelopment of bacterial resistant acrylamide-polyvinylpyrrolidonemetal oxide hydrogel nanocomposites
dc.title.journalMaterials Today-Proceedings
dc.typeJournal Article
dspace.entity.typePublication
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