Novel insights into the role of chromatin remodeler MORC2 in cancer

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dc.contributor.authorSyed, Khajamohiddin
dc.contributor.authorChutani, Namita
dc.contributor.authorBabu, Pakala Suresh
dc.contributor.authorRagula, Sandhya
dc.coverageBasel, Switzerland
dc.coverage.conferenceissn
dc.date.accessioned2026-02-13T11:52:11Z
dc.date.available2026-02-13T11:52:11Z
dc.date.issued2023
dc.departmentNameBiochemistry and Microbiology
dc.description.abstractA newly discovered chromatin remodeler, MORC2, is a Microrchidia (MORC) family member. MORC2 acts as a chromatin remodeler by binding to the DNA and changing chromatin conformation using its ATPase domain. MORC2 is highly expressed in a variety of human cancers. It controls diverse signaling pathways essential for cancer development through its target genes and interacting partners. MORC2 promotes cancer cells’ growth, invasion, and migration by regulating the expression of genes involved in these processes. MORC2 is localized primarily in the nucleus and is also found in the cytoplasm. In the cytoplasm, MORC2 interacts with adenosine triphosphate (ATP)-citrate lyase (ACLY) to promote lipogenesis and cholesterogenesis in cancer. In the nucleus, MORC2 interacts with the transcription factor c-Myc to control the transcription of genes involved in glucose metabolism to drive cancer cell migration and invasion. Furthermore, MORC2 recruits on to the promoters of tumor suppressor genes to repress their transcription and expression to promote oncogenesis. In addition to its crucial function in oncogenesis, it plays a vital role in DNA repair. Overall, this review concisely summarizes the current knowledge about MORC2-regulated molecular pathways involved in cancer.
dc.facultyFaculty of Science, Agriculture and Engineering
dc.identifier.citationChutani, N., Ragula, S., Syed, K. and Pakala, S.B., 2023. Novel insights into the role of chromatin remodeler MORC2 in cancer. Biomolecules, 13(10), pp.1-12.
dc.identifier.otherhttps://doi.org/10.3390/biom13101527
dc.identifier.urihttp://hdl.handle.net/10530/58709
dc.inproceedingsissn
dc.issuenumber13 / 10
dc.keynoteissn
dc.language.isoen
dc.pages1 - 12
dc.peerreviewedYes
dc.publisherMDPI
dc.subjectMORC2
dc.subjectChromatin remodeling
dc.subjectTranscription of genes
dc.subjectPost-translational modifications
dc.subjectCancer invasion and migration
dc.subjectMetabolism
dc.titleNovel insights into the role of chromatin remodeler MORC2 in cancer
dc.title.journalBiomolecules
dc.typeJournal Article
dspace.entity.typePublication
relation.isAuthorOfPublication89f4c77e-bc15-4300-bf81-aa80397b8a69
relation.isAuthorOfPublication.latestForDiscovery89f4c77e-bc15-4300-bf81-aa80397b8a69
relation.isOrgUnitOfPublication13ff708a-670d-4a85-bc85-e77baba2a8b1
relation.isOrgUnitOfPublication.latestForDiscovery13ff708a-670d-4a85-bc85-e77baba2a8b1
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