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- Diabetic cardiomyopathy (DCM) pathogenesis is complex, and the management options for DCM are limited. This study was designed to investigate the effect of Gongronema latifolium leaf extract on DCM in alloxan-induced diabetic rats. Alloxan monohydrate was used to induce diabetes by an intraperitoneal injection of (150 mg/kg). Three diabetic groups were administered aqueous leaf extract of Gongronema latifolium at 6.36, 12.72, and 25.44 mg/kg bodyweight (BW) respectively; a group was administered with metformin (5 mg/kg BW), while the other two served as positive and negative control. Thereafter, fasting blood glucose, antioxidant enzymes, malondialdehyde level, serum lactate dehydrogenase, creatine kinase-MB, cardiac Troponin I, C-reactive protein, and TNF-α were determined by standard methods. Aqueous extract of Gongronema latifolium leaf significantly (p < 0.05) reduced the alloxan-induced increases in blood glucose, malondialdehyde, serum lactate dehydrogenase, creatine kinase-MB, cardiac Troponin I, C-reactive protein, and tumor necrosis factor-α and increased the alloxan-induced decreases in superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione, and glutathione transferase activities. All these changes were compared with those of metformin-treated diabetic rats. The data from this study suggest that aqueous extract of Gongronema latifolium ameliorated DCM by inhibiting redox imbalance and inflammation in diabetic rats.
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- Background: Gongronema latifolium leaf is used traditionally to treat diabetes and other diseases. The present study aimed to provide the modulatory effect of G. latifolium on hyperglycemia, inhibitory effect of redox imbalance and inflammation in alloxan-induced nephropathy in Wistar rats. Methods: Alloxanmonohydratewasusedtoinducediabetesbyanintraperitonealinjection of(150mg/kg).Three diabetic groups were administered aqueous leaf extract of G. latifolium at 6.36, 12.72 and 25.44 mg/kg bodyweight (BW) respectively; a group was administered with metformin (5 mg/kg BW), while the other two were served as positive and negative control. Thereafter, fasting blood glucose, antioxidant enzymes, malondialdehyde (MDA) level, interleukin 2 and 6 were determined. Results: G. latifolium leaf significantly (p < 0.05) reduced the alloxan-induced increases in blood glucose, MDA, interleukin 2 and interleukin 6 level and increased the alloxan-induced decreases in superoxide dismutase, catalase, glutathione peroxidase, glutathione reduced and glutathione transferase activity. All these changes compared with those of metformin-treated diabetic rats. Conclusion: The data from this study suggest that G. latifolium modulates glucose homeostasis as well as inhibiting redox imbalance and inflammation in diabetic rats, which may be attributed to the effects of its phytochemical constituents such as saponins, flavonoids and alkaloids. It also indicated that inhibition of inflammatory cytokines and redox imbalance are likely mechanisms by which G. latifolium leaf exert its antidiabetic action.
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