20232
Author: Osukoya, Olukemi × Subject: Syringic acid ×
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    Methyl cellosolve-induced hepatic oxidative stress: the modulatory effect of syringic acid on Nrf2-Keap1-Hmox1-NQO1 signaling pathway in rats
    2023
     | Elsevier
    Ethnopharmacological relevance: Syringic acid (SAC) is a phenolic compound and an antioxidant that has been identified in honey, grapes, red wine, marigold and sugar apple. Due to its potent antioxidant prowess, SAC possesses hepatoprotective, nephroprotective, neuroprotective, cardioprotective and anti-inflammatory activities. Aim of the study: Judging by these credentials, this study investigated the effect of 25, 50 and 75 mg/kg body weight of SAC on hepatotoxicity induced by 100 mg/kg body weight of methyl cellosolve (MECE) in male Wistar rats. Results: Compared with control, MECE decreased the liver relative weight, nitric oxide (NO) concentration, glutathione S-transferase (GST), glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) activities, while liver malondialdehyde (MDA), nuclear factor erythroid 2-related factor 2 (Nrf2), Kelch-like ECH associated protein 1 (Keap1), heme oxygenase 1 (Hmox1) and NAD(P)H quinone oxidoreductase 1 (NQO1) levels were significantly increased. Treatments with 25, 50 and 75 mg/kg of SAC significantly decreased the concentration of MDA, Nrf2, Keap1 (by 50 and 75 mg/kg only), mRNA expressions of Hmox1, NQO1 and increased the concentration of NO, activities of GPx, GST, SOD and CAT compared with MECE only administered rats. Conclusion: In conclusion, SAC demonstrated a strong hepatoprotective role against MECE-induced hepatic depletion of endogenous antioxidant enzymes and inhibition of MECE-induced cytosolic Nrf2 activation and antioxidant response element (ARE)-dependent genes in rats.
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    Syringic acid ameliorates testicular oxidative stress via the conservation of endogenous antioxidant markers and inhibition of the activated Nrf2-Keap1-NQO1-HO1 signaling in methyl cellosolve-administered rats
    2023
     | Elsevier
    Introduction: Syringic acid (SYRAC) isolated from Ban Lan Gen or Isatis root, a famous Chinese traditional medicine is known to possess antiendotoxic effect. Methyl cellosolve (MCE) on the other hand, is an impor- tant constituent of car brake fluids, pesticides, inks, paints, and liquid soaps, rendering humans inevitable to its exposure. Methods: This study therefore investigated the effect of SYRAC treatments on MCE-induced testicular oxidative stress in rats. Six (6) groups of five (5) rats each were involved in this study that lasted for 30 days. The first group was the control that contained rats served food and water throughout, the second group were administered 100 mg/kg body weight of MCE everyday for 30 days, the third, fourth, and fifth group were treated same way as rats in second group but were treated with 25, 50, and 75 mg/kg body weight of SYRAC respectively for 30 days, while rats in the sixth group were administered 75 mg/kg body weight of SYRAC only. Results: At the end of administrations, RTW, testicular GSH level, and activities of GPx, GST, CAT, and SOD were significantly decreased, while MDA, total mRNA expressions of HO-1, NQO1, Keap1, and Nrf2 were significantly increased by MCE compared with control. Compared with MCE only, treatments with SYRAC significantly in- creased the testicular levels of NO and GSH, as well as activities of GPx, GST, SOD, and CAT, while MDA, mRNA expressions of Keap1, NQO1, Nrf2, and HO-1 were significantly decreased. Conclusion: Conclusively, MCE-induced testicular oxidative stress was recorded. SYRAC demonstrated a gonado- protective effect by maintaining the normal levels of the endogenous antioxidants and inhibiting MECE-induced Nrf2 activation and ARE-dependent genes in rats.
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