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Journal Article
Ameliorative effect of flavonoid-rich extracts from Gongronema latifolium against diabetic cardiomyopathy via serpin A3 and socs3-a in streptozocin treated rats
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Abstract:
Introduction: The present study access the effect of the flavonoid-rich extract from Gongronema latifolium against cardiomyopathy streptozotocin-induced diabetic rats.
Materials and methods: The flavonoid-rich extract from G. latifolium leaf (FREGL) was prepared using a standard method. Diabetes was induced by a single intraperitoneal (i.p.) injection of streptozotocin. The experimental animals were divided into five groups as non-diabetic rats, diabetic control, diabetic rats administered low and high doses of FREGL (13 and 26 mg/kg), and metformin-glibenclamide orally for 21 days. Hence, the experimental animals were sacrificed; blood and heart were harvested to determine diverse biochemical parameters, including the gene expressions of serpin A3 and socs3-a as well as histological examination.
Results: The results demonstrated that FREGL significantly (p < 0.05) reduced fasting blood glucose, total cholesterol, low density lipoprotein (LDL), triglyceride (TG), lipid peroxidation levels, as well as the activities of lactate dehydrogenase and creatine kinase-MB, including the relative gene expressions of serpin A3 and Socs3-A in diabetic rats. Also, diabetic rats that received different doses of FREGL showed a substantial rise in insulin and high density lipoprotein (HDL) levels, antioxidant enzyme activities, as well as, normal histoarchitecture of the heart tissues.
Conclusion: Therefore, FREGL may be beneficial in alleviating diabetic cardiomyopathy.
Other Titles: Ameliorative effect of flavonoid-rich extracts from Gongronema latifolium against diabetic cardiomyopathy via serpin A and socs3-a in streptozocin treated rats
Citation: Oyinloye, B.E., Ajiboye, B.O., Johnson, O., Owolabi, O.V., Ejeje, J.N., Brai, B.I. and Omotuyi, O.I. 2022. Ameliorative effect of flavonoid-rich extracts from Gongronema latifolium against diabetic cardiomyopathy via serpin A3 and socs3-a in streptozocin treated rats. Biomarkers, 27(2), pp.169-177.
Other: https://doi.org/10.1080/1354750X.2021.2023220
Journal Title: Biomarkers
Journal Issue / Part Number: 27 / 2
Peer reviewed: Yes
ISSN: 1366-5804 (online)
Other: https://doi.org/10.1080/1354750X.2021.2023220
Publisher: Taylor & Francis
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