Ameliorative effect of flavonoid-rich extracts from Gongronema latifolium against diabetic cardiomyopathy via serpin A3 and socs3-a in streptozocin treated rats

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dc.contributor.authorOyinloye, Babatunji Emmanuel
dc.contributor.authorAjiboye, Basiru Olaitan
dc.contributor.authorJohnson, Oluwafolakemi
dc.contributor.authorOwolabi, Olutunmise Victoria
dc.contributor.authorEjeje, Jerius Nkwuda
dc.contributor.authorBrai, Batholemn I.C.
dc.contributor.authorOmotuyi, Olaposi Idowu
dc.date.accessioned2026-03-27T07:47:14Z
dc.date.available2026-03-27T07:47:14Z
dc.date.issued2022
dc.departmentNameBiochemistry and Microbiology
dc.description.abstractIntroduction: The present study access the effect of the flavonoid-rich extract from Gongronema latifolium against cardiomyopathy streptozotocin-induced diabetic rats. Materials and methods: The flavonoid-rich extract from G. latifolium leaf (FREGL) was prepared using a standard method. Diabetes was induced by a single intraperitoneal (i.p.) injection of streptozotocin. The experimental animals were divided into five groups as non-diabetic rats, diabetic control, diabetic rats administered low and high doses of FREGL (13 and 26 mg/kg), and metformin-glibenclamide orally for 21 days. Hence, the experimental animals were sacrificed; blood and heart were harvested to determine diverse biochemical parameters, including the gene expressions of serpin A3 and socs3-a as well as histological examination. Results: The results demonstrated that FREGL significantly (p < 0.05) reduced fasting blood glucose, total cholesterol, low density lipoprotein (LDL), triglyceride (TG), lipid peroxidation levels, as well as the activities of lactate dehydrogenase and creatine kinase-MB, including the relative gene expressions of serpin A3 and Socs3-A in diabetic rats. Also, diabetic rats that received different doses of FREGL showed a substantial rise in insulin and high density lipoprotein (HDL) levels, antioxidant enzyme activities, as well as, normal histoarchitecture of the heart tissues. Conclusion: Therefore, FREGL may be beneficial in alleviating diabetic cardiomyopathy.
dc.facultyFaculty of Science, Agriculture and Engineering
dc.identifier.citationOyinloye, B.E., Ajiboye, B.O., Johnson, O., Owolabi, O.V., Ejeje, J.N., Brai, B.I. and Omotuyi, O.I. 2022. Ameliorative effect of flavonoid-rich extracts from Gongronema latifolium against diabetic cardiomyopathy via serpin A3 and socs3-a in streptozocin treated rats. Biomarkers, 27(2), pp.169-177.
dc.identifier.issn1366-5804 (online)
dc.identifier.issn1354-750X (print)
dc.identifier.otherhttps://doi.org/10.1080/1354750X.2021.2023220
dc.identifier.urihttp://hdl.handle.net/10530/59053
dc.issuenumber27 / 2
dc.language.isoEnglish
dc.pages169 - 177
dc.peerreviewedYes
dc.publisherTaylor & Francis
dc.subjectIsolate
dc.subjectFlavonoid
dc.subjectHistology
dc.subjectGene expression
dc.subjectAntioxidant enzymes
dc.subjectLipid profiles
dc.titleAmeliorative effect of flavonoid-rich extracts from Gongronema latifolium against diabetic cardiomyopathy via serpin A3 and socs3-a in streptozocin treated rats
dc.title.alternativeAmeliorative effect of flavonoid-rich extracts from Gongronema latifolium against diabetic cardiomyopathy via serpin A and socs3-a in streptozocin treated rats
dc.title.journalBiomarkers
dc.typeJournal Article
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery7a853ed9-a20d-49e7-b740-c303f88993a2
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relation.isOrgUnitOfPublication.latestForDiscovery13ff708a-670d-4a85-bc85-e77baba2a8b1
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