In vitro antiviral, antioxidant and in vivo antipyretic activity of three South Africa medicinal plants crude extracts

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dc.contributor.authorOsunsanmi, Foluso Oluwagbemiga
dc.contributor.authorYotwana, Lungelo
dc.contributor.authorMosa, Rebamang A.
dc.contributor.authorLiu, Ai-Lin
dc.contributor.authorGao, Li
dc.contributor.authorDu, Guan-Hua
dc.contributor.authorOpoku, Andrew Rowland
dc.coverage.conferenceissn
dc.date.accessioned2026-02-26T07:11:32Z
dc.date.available2026-02-26T07:11:32Z
dc.date.issued2022
dc.departmentNameAgriculture
dc.description.abstractThis study investigated anti-viral, antioxidant activity and anti-pyretic of crude extract from Artemisia afra, Artemisia absinthium and Pittiosporum viridflorum leaves. The crude extracts were prepared by maceration using aqueous, methanol and dichloromethane respectively. Antiviral studies were evaluated with influenza virus using Fluorescence based - Neuraminidase inhibitors. Antioxidant activities determined with DPPH, Nitric oxide, hydroxyl and super oxide anion radicals’ Anti-pyretic activities were evaluated using rats with yeast induced pyrexia. Total phenol, flavonoids, and proanthocyanin contents of the plants samples were evaluated using standard protocols. The crude extracts exhibited neuraminidase inhibitory activity against the influenza virus at different thresholds. Artemisia absinthium aqueous extract showed the best activity against A/Sydney/5/97. Whereas Artemisia afra methanol crude extract displayed highest antioxidant potential against the tested antioxidant parameters. All the crude extracts significantly reversed yeast induced pyrexia in rats, similar to paracetamol. Thus, they could serve as natural remedy for respiratory diseases such as Influenza.
dc.facultyFaculty of Science, Agriculture and Engineering
dc.identifier.citationOsunsanmi, F.O., Yotwana, L., Mosa, R.A., Liu, A.L., Gao, L., Du, G.H. and Opoku, A.R. 2022. In vitro antiviral, antioxidant and in vivoantipyretic activity of three South Africa medicinal plants. Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants, 21(5), pp.620-630.
dc.identifier.issn0717-7917 (print)
dc.identifier.otherhttps://doi.org/10.37360/blacpma.22.21.5.38
dc.identifier.urihttp://hdl.handle.net/10530/58866
dc.inproceedingsissn
dc.issuenumber21 / 5
dc.keynoteissn
dc.language.isoen
dc.pages620 - 630
dc.peerreviewedYes
dc.publisherUniversity of Santiago
dc.subjectAntiviral
dc.subjectAntioxidant
dc.subjectArtemisia afra
dc.subjectArtemisia absinthium
dc.subjectPittosporum viridiflorum
dc.titleIn vitro antiviral, antioxidant and in vivo antipyretic activity of three South Africa medicinal plants crude extracts
dc.title.journalLatin American and Caribbean Bulletin of Medicinal and Aromatic Plants
dc.typeJournal Article
dspace.entity.typePublication
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relation.isAuthorOfPublicationd9dc111c-896b-4cca-8263-3637771900e9
relation.isAuthorOfPublication.latestForDiscovery33bc572a-c3af-4677-8b3b-499e9424c882
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relation.isOrgUnitOfPublication.latestForDiscovery4866ce54-8485-473a-8708-7be01d87e538
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