Detrimental effects of lipid peroxidation in type 2 diabetes: exploring the neutralizing influence of antioxidants

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dc.contributor.authorShabalala, Samukelisiwe
dc.contributor.authorJohnson, Rabia
dc.contributor.authorBasson, Albertus K.
dc.contributor.authorZiqubu, Khanyisani
dc.contributor.authorHlengwa, Nokulunga
dc.contributor.authorMthembu, Sinenhlanhla X. H.
dc.contributor.authorMabhida, Sihle E.
dc.contributor.authorMazibuko-Mbeje, Sithandiwe E.
dc.contributor.authorHanser, Sidney
dc.contributor.authorCirilli, Ilenia
dc.contributor.authorTiano, Luca
dc.contributor.authorDludla, Phiwayinkosi V.
dc.coverageBasel, Switzerland
dc.coverage.conferenceissn
dc.date.accessioned2026-03-24T06:35:57Z
dc.date.available2026-03-24T06:35:57Z
dc.date.issued2022
dc.departmentNameBiochemistry and Microbiology
dc.description.abstractLipid peroxidation, including its prominent byproducts such as malondialdehyde (MDA) and 4-hydroxy-2-nonenal (4-HNE), has long been linked with worsened metabolic health in patients with type 2 diabetes (T2D). In fact, patients with T2D already display increased levels of lipids in circulation, including low-density lipoprotein-cholesterol and triglycerides, which are easily attacked by reactive oxygen molecules to give rise to lipid peroxidation. This process severely depletes intracellular antioxidants to cause excess generation of oxidative stress. This consequence mainly drives poor glycemic control and metabolic complications that are implicated in the development of cardiovascular disease. The current review explores the pathological relevance of elevated lipid peroxidation products in T2D, especially highlighting their potential role as biomarkers and therapeutic targets in disease severity. In addition, we briefly explain the implication of some prominent antioxidant enzymes/factors involved in the blockade of lipid peroxidation, including termination reactions that involve the effect of antioxidants, such as catalase, coenzyme Q10, glutathione peroxidase, and superoxide dismutase, as well as vitamins C and E.
dc.facultyFaculty of Science, Agriculture and Engineering
dc.identifier.citationShabalala, S.C. et al. 2022. Detrimental effects of lipid peroxidation in type 2 diabetes: exploring the neutralizing influence of antioxidants. Antioxidants, 11(10), pp.1-17.
dc.identifier.issn2076-3921 (online)
dc.identifier.otherhttps:// doi.org/10.3390/antiox11102071
dc.identifier.urihttp://hdl.handle.net/10530/58997
dc.inproceedingsissn
dc.issuenumber11 / 10
dc.keynoteissn
dc.language.isoEnglish
dc.pages1 - 17
dc.peerreviewedYes
dc.publisherMDPI
dc.subjectLipidperoxidation
dc.subjectOxidative stress
dc.subjectAntioxidants
dc.subjectInflammation
dc.subjectType 2 diabetes
dc.subjectMetabolic complications
dc.titleDetrimental effects of lipid peroxidation in type 2 diabetes: exploring the neutralizing influence of antioxidants
dc.title.journalAntioxidants
dc.typeJournal Article
dspace.entity.typePublication
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