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Journal Article
Detrimental effects of lipid peroxidation in type 2 diabetes: exploring the neutralizing influence of antioxidants
Author(s): Johnson, Rabia; Ziqubu, Khanyisani; Mthembu, Sinenhlanhla X. H.; Mabhida, Sihle E.; Mazibuko-Mbeje, Sithandiwe E.; Hanser, Sidney; Cirilli, Ilenia; Tiano, Luca; Shabalala, Samukelisiwe; Basson, Albertus K.; Hlengwa, Nokulunga; Dludla, Phiwayinkosi V.
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Issue Date: 2022
Language: English
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Abstract: Lipid peroxidation, including its prominent byproducts such as malondialdehyde (MDA) and 4-hydroxy-2-nonenal (4-HNE), has long been linked with worsened metabolic health in patients with type 2 diabetes (T2D). In fact, patients with T2D already display increased levels of lipids in circulation, including low-density lipoprotein-cholesterol and triglycerides, which are easily attacked by reactive oxygen molecules to give rise to lipid peroxidation. This process severely depletes intracellular antioxidants to cause excess generation of oxidative stress. This consequence mainly drives poor glycemic control and metabolic complications that are implicated in the development of cardiovascular disease. The current review explores the pathological relevance of elevated lipid peroxidation products in T2D, especially highlighting their potential role as biomarkers and therapeutic targets in disease severity. In addition, we briefly explain the implication of some prominent antioxidant enzymes/factors involved in the blockade of lipid peroxidation, including termination reactions that involve the effect of antioxidants, such as catalase, coenzyme Q10, glutathione peroxidase, and superoxide dismutase, as well as vitamins C and E.
Citation: Shabalala, S.C. et al. 2022. Detrimental effects of lipid peroxidation in type 2 diabetes: exploring the neutralizing influence of antioxidants. Antioxidants, 11(10), pp.1-17.
Publication Place: Basel, Switzerland
Other: https:// doi.org/10.3390/antiox11102071
Journal Title: Antioxidants
Journal Issue / Part Number: 11 / 10
Peer reviewed: Yes
International Conference: issn
Keynote / Plenary: issn
In Proceedings: issn
ISSN: 2076-3921 (online)
Other: https:// doi.org/10.3390/antiox11102071
Publisher: MDPI
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